If you’re using Chrome and Spotify on macOS and the Play/Pause buttons on your keyboard are not working when using Spotify, there’s a simple fix for this.

Spotify Play/Pause Buttons on macOS

First, navigate to chrome://flags/#hardware-media-key-handling in Chrome.

Next, set the option for Hardware Media Key Handling as Disabled.

Lastly, when prompted to restart Chrome, go ahead and do so and the keys should work.